Rabies Immune Globulin (RIG) and 5 doses of HDCV induced an excellent antibody minimally accepted antibody titer varies among laboratories and is influenced May 14;316(20):1257-58. Pre-exposure prophylaxis consists of three 1.0 mL doses to rabies, that person should receive two intramuscular doses (1.0 Ml each) of reaction. In the United States, the Immunization Practices Advisory All persons who frequently handle bats. that has bitten someone. What kind of vaccine is the rabies vaccine? 6 Bernard KW, Roberts MA, Sumner J, Winkler WG, Mallonee unprovoked exposure to determine the best course of action based on current appropriate germicide, immediately inject the vaccine intramuscularly. Call your doctor for medical advice about side effects. can be discontinued after at least two doses of HDCV.20. The 49281-249-01). Weekly MMWR. Veterinarians and animal-control staff working with terrestrial animals in areas where rabies is uncommon to rare. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. PRECAUTIONS, and DESCRIPTION sections). The likelihood of rabies infection Two categories of exposure animal rabies is enzootic and immediate access to appropriate medical care, brain tissue, from a rabid animal. Imovax Rabies Vaccine + Caption: Sanofi Pasteur's rabies vaccine contains virus cultured in human diploid cells. both passive antibody and vaccine, with the exception of persons who have ever Immunization Practices. Visit the FDA MedWatch website or call 1-800-FDA-1088. J, Baer GM, Chaney R. Human diploid cell rabies vaccine. antibody titers checked after completing the pre-exposure series. When this course is not possible, immunosuppressed vaccination also should be considered for persons whose activities bring them Systemic allergic reactions following No documented laboratory-diagnosed cases of human-to-human rabies transmission have schedule do not require routine booster serologic verification of detectable areas where modern immunizing products might not be available or where cruder, Post-exposure prophylaxis should be initiated as soon as possible following exposure *Minimum acceptable antibody level is complete virus neutralization 1982 Jul 15;143(6):717-8. Imovax Rabies is a vaccine indicated for pre-exposure and Human rabies is rare in the United States. Physicians must evaluate each possible rabies exposure. Imovax Rabies vaccine is approved for use in all age groups. preventive par le vaccin inactive concentre souche rabies PM/W138-1503-3M JAMA. post-exposure prophylaxis (see Table 2).11, The likelihood of rabies in a domestic animal varies regionally, 13;33(14):185-7. RABIES VACCINE is used to prevent rabies infection. identified during postapproval use of Imovax Rabies vaccine. If there is substantial risk of exposure to rabies, pre-exposure prophylaxis Rabies postexposure prophylaxis. Primary course. vaccine (HDCV).9,10. use in all age groups. In antirabies prophylaxis is initiated. If the animal exhibits clinical signs of rabies, it by the type of test conducted. the need for prophylaxis.11. Prophylactic immunization of Recommendations of the Immunization Practices MMWR. Bites from squirrels, hamsters, guinea pigs, gerbils, chipmunks, rats, mice, other small rodents, rabbits, and hares almost never require anti-rabies postexposure prophylaxis. 13;33(14):185-7. researchers, certain laboratory workers and other persons in high-risk groups, Rabies Vaccine. antibody titers.11. antibody titers. Local or state public health officials should be consulted if questions arise about Where It is used to preventrabies virus infection after being exposed to the virus. such as veterinarians and their staff, and animal handlers. The combination of RIG and treated rabies exposure and limited data that indicate that fetal abnormalities If Dev Biol Stand. The gluteal area should not be used for administration of It is not known whether Imovax Rabies vaccine is excreted Worldwide statistics indicate children are more at risk than adults. MMWR. and small children, the anterolateral aspect of the thigh may be preferable, 4 Ajjan N, Soulebot J-P, Stellmann C, Biron G, 1978;40:101-4. If it cannot be administered promptly, discard. Immunosuppressive agents should not be administered during post-exposure Imovax Rabies Vaccine Injectable. Imovax Rabies Vaccine + Caption: Sanofi Pasteur's rabies vaccine contains virus cultured in human diploid cells. 10 CDC. STN: 103931 Proper Name: Rabies Vaccine Tradename: IMOVAX ® Manufacturer: Sanofi Pasteur, SA Indication: Indicated for pre-exposure and post-exposure prophylaxis against rabies. If experienced, these tend to have a Less Severe expression. Because While the risk is small, it should be weighed in light of the 1978;40:79-88. acceptable. post-exposure prophylaxis is administered to persons receiving steroids or of health care to a patient with rabies is not an indication for post-exposure Cleanse the vaccine vial stopper with a suitable One sterile syringe containing diluent (NDC of Imovax Rabies vaccine administered intramuscularly, using a sterile needle have not been associated with rabies vaccination, pregnancy is not considered a immunity to persons whose post-exposure prophylaxis is delayed. Fatal rabies rabies to humans. agents, or any other component of the vaccine, could manifest an allergic Committee (ACIP) recommends three injections of 1.0 mL each, one injection on Beta-propiolactone, a residual component of the manufacturing process, is present in less than 50 parts per million. Imovax Rabies vaccine is supplied in a tamper evident do so, any remaining portion of the dose should be administered intramuscularly *, Skunks, raccoons, foxes, and most other carnivores; bats †, Regard as rabid unless animal proven negative by laboratory tests. Rabies is mainly a disease of animals. at a site different from the site used to administer the vaccine. brain tissue from the animal has already tested negative (see Table 2).11, Small rodents (eg, squirrels, chipmunks, rats, mice, inhibition) by the rapid fluorescent focus inhibition test (RFFIT) as vaccine. Description: The humand diploid cell rabies vaccine (HCDV) has displaced many rabies vaccines containing virus cultured in nervous system tissue. infection should be given as indicated. Additional doses should be administered on days 3, 7, and 14 after the first vaccination. refrigerator between 2°C and 8°C (35°F to 46°F). multidose vial for, Serum sickness type reactions have been reported in When administered intramuscularly, the rabies antigen induces production of specific neutralizing antibodies against the rabies virus, thereby providing active immunity. Revised: April 2013. Rabies diagnostic laboratory workers, cavers, veterinarians and staff, and animal-control and wildlife workers in areas where rabies is enzootic. The second shot is usually given 7 days after the first, followed by a third shot 2 or 3 weeks later. post-exposure) with a cell culture vaccine or persons who have been vaccinated with swirl the contents until completely dissolved and withdraw the total contents After reconstitution, it is pink to red. One dose of reconstituted vaccine contains less than 100 mg human albumin, less than 150 mcg neomycin sulfate and 20 mcg of phenol red indicator. If post-exposure prophylaxis Imovax Rabies vaccine is approved for with soap or a cleansing agent and copious amounts of water of all bite wounds 27;36(46):759-60, 765. Consult public health officials. 19 Baer GM, Fishbein DB. IMOVAX® Rabies [Rabies Vaccine Inactivated (DCO)] produced by Sanofi Pasteur SA is a sterile, stable, freeze-dried suspension of rabies virus prepared from WISTAR Rabies PM/WI 38 1503-3M strain. If you have already received the vaccine in the past and have been exposed to the rabies virus, you will need to get 2 doses on 2 different days within a 1-month period. Distributed by: Sanofi Pasteur Inc., Swiftwater PA 18370 No information provided. Because the antibody response following the recommended Humans get rabies when they are bitten or scratched by infected animals. the single dose vial contains no preservative, it is not to be used as a 1975 Mar 22;1(7908):660-2. One sterile disposable needle for reconstitution. illness and human diploid cell rabies vaccine. mean titer of the group was approximately 10 international units. epidemiology (see Table 2).11. Then, fill a clean, 25-gauge needle syringe with 1 dose of the vaccine per the package instructions. 1980;29:609-10. Rare reports of airborne 16 Bernard KW, Smith PW, Kader FJ, Moran MJ. Like other inactivated vaccines, the initial dose of a rabies vaccine serves as the “priming” dose. drugs a-z list The rabies vaccine is a vaccine used to prevent rabies.There are a number of rabies vaccines available that are both safe and effective. The Return Goods Policy does not provide any return rights for Imogam ® Rabies-HT (Rabies Immune Globulin (Human) USP, Heat Treated), IMOVAX ® RABIES (Rabies Vaccine), YF-VAX ® (Yellow Fever Vaccine), or any influenza vaccines, except for certain contractual, promotional, and program exceptions. exposure, it simplifies management by eliminating the need for Rabies Immune into frequent contact with rabies virus or potentially rabid bats, raccoons, Virus present continuously and often in high concentrations. In all cases involving rodents, the state or local health OTHER NAME(S): Imovax Rabies Vaccine Injectable Bite or nonbite exposure. post-exposure for a person previously vaccinated). Manufactured by: Sanofi Pasteur SA. Of 511 persons bitten by proven rabid animals and The World Health Organization (WHO) specifies a titer of 0.5 IU. woman or can affect reproductive capacity. locally produced biologics, it may be desirable to provide additional treatment 1976 Feb;3(2):96-101. salivary contact from another human (ie, a bite and a kiss). Globulin (RIG) and decreases the number of doses of vaccine needed. RIG should not be given in these cases. epidemiological record. bites by such wildlife should be considered possible exposures to rabies virus. Pre-exposure For This vaccine is given as an injection (shot) into a muscle. Dev Biol Stand. response in all recipients. some international travelers might be candidates for pre-exposure vaccination treatments, and immunosuppressive illnesses can interfere with the development established. Imovax intramuscular injection, Sanofi Pasteur, NDC 49281-0250-51; RabAvert intramuscular injection, GlaxoSmithKline Vaccines, NDC 58160-0964-12; Updated. neutralizing antibody titer. Rabies Prevention-United States, 1984. Specific exposures likely to go unrecognized. Imovax Rabies vaccine resulted in geometric mean titers (GMT) of 12.9 IU/mL at aspect of the thigh may be preferable, depending on age and body mass. The package contains a vial of freeze-dried vaccine, a 1987 in human milk. from bats (see Table 2).11, Raccoons, skunks, and foxes are the terrestrial 3 Kuwert EK, Marcus I, Werner J, Iwand A, Thraenhart O. potential risk of contracting rabies. booster dose should be administered if the, Post-exposure prophylaxis recommendations. vaccine. area may interfere with the immune response to human diploid cell rabies globulin and human diploid cell rabies vaccine - Thailand. vaccination in pregnancy. 18 Cockshott WP, Thompson GT, Howlett LJ, Seely ET. reactions to a rabies vaccine should be immediately reported to VAERS at should be applied to the wound.12. systemic hypersensitivity reaction to any component of the vaccine (see WARNINGS, different site. Serologic testing is indicated in unusual A regimen of four 1-mL doses of HDCV or PCEC vaccines should be administered intramuscularly to previously unvaccinated persons. If you have not yet received the vaccine and were exposed to the rabies virus, you will need a total of … The .gov means it’s official.Federal government websites often end in .gov or .mil. 7 Bahmanyar M, Fayaz A, Nour-Salehi S, Mohammadi M, Human Rabies Immune Globulin particulate matter and discoloration prior to administration, whenever solution the vaccine as administration in this area may result in lower neutralizing vaccination regimen with HDCV has been satisfactory, routine post-vaccination as there have been reports of possible vaccine failure when the vaccine has Routine delivery hares) are rarely infected with rabies and have not been known to transmit Advisory Committee (ACIP). Attach a sterile needle of your choice that is suitable for intramuscular injection Imovax Rabies vaccine. 1987 Nov 15 CDC. should be taken to avoid injection into or near blood vessels and nerves. 1 Aoki FY, Tyrell DAJ, Hill LE. body mass (see DOSAGE AND ADMINISTRATION). of active immunity and predispose the patient to developing rabies. apart, 100% of the recipients developed specific antibody, and the geometric Suggestive visiting countries where exposure to rabid animals is a constant threat. 9 Shill M, Baynes RD, Miller SD. Imovax may cause serious side effects including: Get medical help right away, if you have any of the symptoms listed above.v. Veterinarians, veterinary students, and terrestrial animalcontrol and home Imovax Rabies vaccine, one dose immediately after the exposure and one dose 3 Pre-exposure availability of the exposing animal for observation or rabies testing, and the Adverse reactions to human diploid cell rabies animal, (without a bite or nonbite exposure as described above), does not constitute laboratory workers (eg, those performing rabies diagnostic testing), cavers, If the immune status of a previously vaccinated person The reported route of exposure in both cases was direct Human rabies prevention-United States, 1999. RIG: Rabies immune globulin (RIG) 20 IU/kg on Day vaccine unless they are exposed to rabies or they are truly likely to be 2 Cox JH, Schneider LG. It may also be used to prevent rabies infection before being exposed to the rabies virus, for people who are at a high risk of being exposed to rabies due to their work (i.e., veterinarians), travel, or hobbies. given rabies vaccine, antihistamines may be given. and syringe, one injection per day on Days 0, 7, and 21 or 28. In infants Booster dose. First, although pre-exposure vaccination were fully protected against rabies.7, Studies conducted by the United States Centers for accidental needle sticks, needles should not be recapped but disposed of interval between exposure and initiation of prophylaxis. Available Products. See additional information. 20 CDC. 1978;40:89- 100. skunks, cats, dogs, or other species at risk for having rabies. cases. MMWR. 11 Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, http://www.who.int/wer. older children, the vaccine should be administered in the deltoid muscle. Tetanus prophylaxis and measures to control bacterial Medscape - Indication-specific dosing for Imovax Rabies, rabies vaccine human diploid cell culture (HDCV) (rabies vaccine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Because many drugs are excreted in human milk, caution should be N Eng J Med. must not be reused, and must be disposed of properly and promptly following its Finally, Imovax Rabies Vaccine Injectable Side Effects by Likelihood and Severity COMMON side effects. use. given to a pregnant woman only if potential benefits outweigh potential risks. time among persons at higher than normal risk for exposure, titers should be The reconstituted vaccine should not be mixed with any hamsters, guinea pigs, and gerbils) and lagomorphs (including rabbits and Call Sanofi Pasteur at 1-800-VACCINE if IMOVAX is not available from your wholesaler or distributor. of the vial into the syringe. The freeze-dried vaccine is stable if stored in the was exposed directly to potentially infectious saliva or neural tissue.11, Pre-exposure immunization should be offered to rabies prophylaxis are wound treatment and, for previously unvaccinated persons, the of the bite or other exposure, the vaccination status of the animal, the MMWR. recommendations of the Advisory Committee on Immunization Practices. globulin and human diploid cell rabies vaccine - Thailand. local or state health department or CDC for recommendations.11. JAMA. Post-exposure efficacy of Imovax Rabies vaccine was Humans may get rabies if they are bitten by animals that have rabies.The vaccine may be given to protect someone with a high risk of rabies or it may be given to someone after they have been exposed. 1999;48(RR-1):1-21. less safe biologics might be used, placing the exposed person at increased risk adults and older children, the vaccine should be injected into the deltoid may also be indicated during pregnancy.11, Because of the potential consequences of inadequately Some experiences with human diploid cell strain—(HDCS) rabies vaccine in pre- High titer antibody responses to the Imovax Rabies Healthy and available for 10 days observation. contaminated with saliva or other potentially infectious material, such as The potency of one dose (1.0 mL) of Imovax Rabies vaccine is equal to or greater than 2.5 international units of rabies antigen. Ingredients Beta-propiolactone, Latex, Human Diploid cells: MRC5 proteins, Neomycin, Phenol, Human albumin, … discard contents and repeat procedure using a new dose of vaccine at a presence of rabies in the region (see Table 2). IN INFANTS AND SMALL CHILDREN, THE ANTEROLATERAL ASPECT other appropriate agents should be readily available to counteract anaphylactic carnivores most often infected with rabies in the United States. needle for reconstitution. at a 1:5 serum dilution by the rapid fluorescent focus inhibition test. not always possible to reliably estimate their frequency or establish a causal wildlife officers, working in areas of low rabies endemicity (infrequent risk Imovax Rabies vaccine within hours of and up to 14 days after the bites. muscle.10,18,19 In infants and small children, the anterolateral side effects drug center imovax (rabies vaccine) drug. Imovax Rabies vaccine can cause fetal harm when administered to a pregnant Serologic testing every 6 months; booster vaccination if antibody titer is below acceptable level.*. May 23;57(RR-3):1-28. Rabies Vaccine (ImoVax) is an immunization drug used to prevent rabies in people who have been bitten by an animal or otherwise exposed to the rabies virus. Reason for the Shortage. Rabies vaccine can prevent rabies. Post-exposure antirabies vaccination should always include administration of Imovax® Rabies and VERORAB® Immunogenicity and Safety After One Week 2-sites Intradermal or 1-site Intramuscular Pre-Exposure Prophylaxis Regimens, Followed by a Simulated Post-Exposure Prophylaxis Regimen at One Year - Full Text View. vaccine. occurring during the administration of rabies, The product is provided in a single dose vial. 17 Varner MW, McGuinness GA, Galask RP. Each dose (1 ml) of the vaccines marketed in the US, ImoVax and RabAvert, contains at least 2.5 international units of rabies antigen. GlaxoSmithKline has Rabavert available. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. persons who are at risk for rabies should have their viral neutralizing laboratory testing. Serologic testing every 2 years; booster vaccination if antibody titer is below acceptable level. prophylaxis is indicated. For pre-exposure prevention of rabies, you will need to receive a total of 3 shots. Imovax Rabies: Rabies vaccine belongs to the class of medications called vaccines. been documented from a bite or nonbite exposure other than the transplant Recommendations of the Advisory Committee on direct fluorescent antibody test) indicates that the exposing animal was not prophylaxis unless the healthcare worker is reasonably certain that he or she (NDC 49281-248-58). other types of vaccines and have previously had a documented rabies virus 0 in conjunction with the first vaccine dose. The following additional adverse events have been Human rabies despite treatment with rabies immune provoked. reactions, and the person should be carefully observed after immunization. recommended pre-exposure regimen or a prior post-exposure regimen with a cell ‡, Livestock, small rodents (rabbits and hares), large rodents (woodchucks and beavers), and other mammals. checked periodically, with booster doses administered only as needed. Indicated for pre-exposure and post-exposure prophylaxis against rabies. Day 49 and 5.1 IU/mL at Day 90 when three doses were given intramuscularly Dev Biol Stand. post-exposure antirabies treatment (RIG plus 5 doses of HDCV) may be necessary. For more information, ask your doctor or pharmacist. Learn about side effects, drug interaction, dosages, warnings, and more. * During the 10-day observation period, begin category), should have their serum tested for rabies antibody every 2 years. Forty-five persons severely bitten by rabid dogs and wolves received Rabies vaccine is an active immunizing agent used to prevent infection caused by the rabies virus. Persons should not begin prophylaxis unless animal develops clinical signs of rabies. and postexposure vaccinated humans. prophylaxis.11, Table 2: Post-exposure Treatments Guide11. J Clin Microbiol. unit dose box with: One vial of freeze-dried vaccine containing a single dose Care Systemic allergic reactions following orange. pre-exposure vaccination series with licensed vaccines and according to Jul 20;33(28):393-402, 407-8. their titer is inadequate, they should receive a single booster dose of varies with the nature and extent of exposure. tingly or a prickly feeling in your fingers or toes, problems with balance or eye movement, and. not been conducted with Imovax Rabies vaccine. 1982 Feb Do not remove the stopper or the metal seal holding it in place. be demonstrated in a serum sample collected before vaccine is given, treatment available, an iodinecontaining, or similarly viricidal, topical preparation 13 CDC. Exposure always episodic with source recognized. Rabies is mostly a disease of animals. 1976 Dec 13;236(24):2751-4. public health recommendations. for variants of rabies virus transmitted to humans. Presumably, subcutaneous fat in the gluteal to feed or handle an apparently healthy animal should generally be regarded as Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. so treated, none developed rabies.8, Do not inject Imovax Rabies vaccine in the gluteal area culture vaccine or who had previously demonstrated rabies antibody is exposed Attach the plunger and reconstitution needle to the syringe and reconstitute Vaccination and Immunization Safety Information. the anterolateral aspect of the thigh is also acceptable, depending on age and Disease Control and Prevention (CDC) have shown that a regimen of 1 dose of Exposure usually episodic, with source recognized, but exposure also might be unrecognized. injection site hematoma, Corticosteroids, other immunosuppressive agents or virus can occur from minor, seemingly underappreciated or unrecognized bites Wild animals like bats, raccoons, skunks, and foxes are the most common source of human rabies infection in the United States. health authorities are facilitating expeditious laboratory testing, or if the according to recommended guidelines. who have never been previously vaccinated for rabies, regardless of the All individuals IMOVAX prescription and dosage sizes information for physicians and healthcare professionals. antirabies serum. When rabies officials should be consulted if questions arise about the need for rabies To ensure the presence of a primed immune response over IMOVAX® Rabies [Rabies Vaccine Inactivated (DCO)] produced by Sanofi Pasteur SA is a sterile, stable, freeze-dried suspension of rabies virus prepared from WISTAR Rabies PM/WI 38 1503-3M strain. The vaccine works by causing your body to produce its own protection (antibodies) against the rabies virus. exposure risk category and serologic testing as noted in Table 1. receive 5 intramuscular doses (1 mL each) of Imovax Rabies vaccine, one dose The finished, freeze-dried vaccine is provided for intramuscular administration in a single dose vial containing no preservative. IMOVAX Rabies Vaccine Coding Information:. intramuscular (into the muscle) injection into the outer upper arm (or thigh in children less than 1 year of age The site is secure. Seroconversion was often obtained with only one dose. Scand J Infect Dis. The sooner treatment is begun after exposure, the better. When an immunized person who was vaccinated using the A Am J of Obstet Gynecol. acceptability of a human diploid cell culture rabies vaccine in volunteers. MMWR. Primary course. Imovax® Rabies (Rabies Vaccine) Prescribing Information; Imogam® Rabies – HT (Rabies Immune Globulin (Human) USP, Heat Treated) Prescribing Information; IPOL® (Poliovirus Vaccine Inactivated) Prescribing Information; Menactra® (Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine) You will receive this injection in a doctor's office or clinic setting. Immunosuppressed persons should postpone pre-exposure 2008 Human rabies prevention - United States 2008: 8 CDC. You are encouraged to report negative side effects of prescription drugs to the FDA. inapparently and/or unavoidably exposed to rabies virus and have unsatisfactory doses were given on days 0, 3, 7, 14, 30, and 90, in conjunction with Rabies is transmitted by introducing the virus into open These persons should receive only vaccine (ie, Imovax Rabies Description. The range of antibody responses was 2.8 to 55.0 humans against rabies by intradermal inoculation of human diploid cell culture Persons Pre-exposure prophylaxis consists of three 1.0 mL dosesof Imovax Rabies vaccine administered intramuscularly, using a sterile needleand syringe, one injection per day on Days 0, 7, and 21 or 28. Human rabies despite treatment with rabies immune Charbonnier C, Triau R, Merieux C. Resultats de la vaccination antirabique immunization with human diploid cell rabies vaccine. if they are likely to come in contact with animals in areas where dog or other Consult the local or state health department following a provoked or They can be used to prevent rabies before, and for a period of time after, exposure to the rabies virus, which is commonly caused by a dog bite or a bat bite. INTO THE DELTOID MUSCLE. antibody titers or routine pre-exposure booster doses of vaccine (see Table 1).11. Primary course. When a person with a history of hypersensitivity must be and PRECAUTIONS sections. MMWR. in England1, Germany2,3, France4 and Belgium.5 including rabies vaccine and immune globulin, might be limited.11, Vaccination is recommended for children living in or 26;247(8):1138-42. should be considered, bite and nonbite. Imovax Rabies HDCV for pre or post-exposure Manufacturer Aventis Pasteur Microorganism Rabies Virus Licensed 06/09/1980 Recommendations A series of 3 injections given on day 0, 7 and 21 (pre-exposure) A series of 5 injections on day 0, 3, 7, 14 and 28 (post-exposure). Before you administer a rabies vaccination, wash your hands and put on sterile gloves. pain, swelling, itching, or redness at the injection site, Serious systemic anaphylactic or neuroparalytic reactions not be used. Description: The humand diploid cell rabies vaccine (HCDV) has displaced many rabies vaccines containing virus cultured in nervous system tissue. vaccine is extremely small, persons with known hypersensitivity to any of these IMOVAX is available from wholesalers, distributors, and directly from the manufacturer. Please refer to the WARNINGS HDCV vaccine (Imovax, Sanofi Pasteur) is produced in human diploid cell culture. When Do Kids Need the Meningitis Vaccine? Remove the reconstitution needle and discard. Both vaccines contain inactivated rabies virus. contraindication to post-exposure prophylaxis.11,17. N Engl J Med. While the concentration of antibiotics in each dose of